What is the scope of physio in CV dysfunction?
What are some of the investigations used for CV dysfunction?
What two factors determine blood pressure?
Mean arterial pressure (MAP) = CO x TPR
How is pulmonary vascular resistance different to systemic?
TPR is much lower than vascular
What causes the difference in blood pressure between systemic and pulmonary circulation?
Differences in vascular resistance mediated by SNS in smooth muscle in the arterioles - increases vasoconstriction & BP
How is blood pressure regulated acutely?
Baroreceptor reflex
Where are baroreceptors located in the heart?
- Aortic arch
What effect does the vagus nerve have on the heart?
- Slows contractility, heart rate etc
How is a decrease in arterial blood pressure regulated by baroreceptors?
How can bed rest affect blood pressure?
24 hours bed rest reduces SNS activity in response to orthostatic (upright) stimulus
What are the symptoms of orthostatic intolerance (low BP)?
What are the reasons for orthostatic intolerance after bed rest (low BP)?
What are the consequences of hypertension?
Major risk factor for
What are the two main things hypertension effects?
- Increases afterload (direct pressure load on left ventricle)
What does increased after load cause?
What does arterial damage cause?
- Weakened vessel wall
What are some of the other CHD risk factors hypertension interacts with?
What is the main cause of hypertension?
Essential (no definitive cause, 95% of cases)
What are the characteristics of essential hypertension (EH)?
- Genetics important
What are the non-pharmacological treatments of hypertension?
What are some of the pharmacological treatments of hypertension?
What is heart failure?
When the heart cannot pump enough blood to meet the requirements of the tissues
What are the types of heart failure?
- Right vs left
What happens in left sided congestive heart failure?