Case Based Learning; GBM

Question 1

Temozolomide

Answer 1

Anti-neoplastic

DNA- alkylation of O6, N7 Guanine

Best BBB penetration!!

CCNS

Used to treat GBM

Question 2

Carmustine

Answer 2

Anti-neoplastic (alkylating agent)

Alkylation/Cross-linking DNA/RNA

Crosses BBB

CCNS

Short half-life. IV, implant

Side Effects: Bone marrow suppression, GI, Liver w/ high doses

Question 3

Vincristine

Answer 3

anti-neoplastic

inhibits microtubule formation

Best antimitotic for crossing BBB… but is poor overall

CCNS

Question 4

What drug is used in addition to anti-mitotics for reducing cerebral edema?

Answer 4

dexamethasone

Question 5

What are the two anti-neoplastics we learned this week that alkylate DNA?