Case Study: Quantitative and Qualitative Platelet Disorder

Question 1

• Prolonged bleeding time
• Larged size platelet
• decreased platelet count
• Decreased or absent response to ristocetin-induced aggregation
• Normal plasma vWF and factor VIII
• Normal response to agonist

Answer 1

Bernard-Soulier Syndrome

Question 2

Prolonged bleeding time
Impaired clot retraction
Normal PT, APTT,and thrombin time
Decreased Platelet antigen PAI1
reduced ang response sa agonist such as ADP, collagen, epinephrine and arachidonic acid

Answer 2

Glanzmann Thrombasthenia