Cathelcidins

Question 1

produced by

Answer 1

neutrophils and barrier epithelial cells in the skin, gastointtesinal tract, and resp. tract

Question 2

synthesized as a 18 kD

Answer 2

two domain precursor that is cleaved in two protective peptides

Question 3

synthesis and cleave

Answer 3

may be stimulated by cytokines and microbes

Question 4

effect

Answer 4

microbes directly through direct toxicity, or indirectly by activating leukocytes

Question 5

LL-37

Answer 5

C terminal fragment, can bind and neutralize LPS

can also play an inflammatory role by binding DNA and blocking AIM2 and inflammasome activation