CB 2

Question 1

integral membrane protein

Answer 1

• b amyloid precursor protein
• abnormal cleavage of B-APP forms AB peptides that aggregate, resistant to proteolysis
• B amyloid precursor protein is important in neuronal migration during development, synaptic formation, and repair, cell signaling, long term potentiation of memory, and cell adhesion
• clinical condition of these plaques= Alzheimers disease

Question 2

Prion Proteins & Creutzfeldt Jakob Disease

Answer 2

• cell surface glycosylated glycophosphatidylinositol GPI anchored protein
• GPI anchor is embedded in lipid rafts
• may be neuroprotective against ischemia, control circadaian rhythms, organize myelin sheath
• conversion of normal PP to a misfolded variant causes aggregation

Question 3

Ceutzfeld Jakob Disease

Answer 3

• ataxia, dementia, paralysis

- spongiform change in cerebrum

Question 4

Kuru

Answer 4

plaques of abnormal aggregates in cerebellum, PAS reaction, congo red

Question 5

membrane proteins as receptors

Answer 5

• pharmacologic agents may act as receptor agonist or antagonist to produce therapeutic effect
• interferes with receptor signaling
• can stimulate receptors

Question 6

secondary active transport

Answer 6

• NA ions and glucose undergo co transport into the cell as sodium moves down its conc gradient which doesnt require energy
• in order to maintain the conc gradient of sodium ions across the membrane sodium that enters with glucose is transported by the Na/K pump, uses energy

Question 7

Dubin Johnson Syndrom

Answer 7

-mutations in the ATP binding region of MDR2 protein, impaired transcription and mislocalization of MDR2 protein

Question 8

Cystic Fibrosis

Answer 8

cholride channel that also regulates Na and HCO3
salty sweat
secretions in intestines, pancreas, bile duct, and airways

Question 9

Vesicular transport types

Answer 9

endocytosis
exocytosis
porocytosis
endosomes