draw CDK activity control diagram

Cdc25 overexpression cells are:
small (shorter G2)
Cdc25+ activates this complex
Cdc2/Cdc13
wee1- mutants cells are:
small (short G2)
cells are larger when Wee1+ is overexpressed due to:
prolonged G2
activity of this is constant throughout cell cycle
CDK
Cdc13+/cyclin forms a complex with:
Cdc2/Cdk
protein Y-kinase that phosphorylates Cdc2/Cdk on Y15
Wee1
affect of Wee1 phosphorylation of Cdc2/Cdk
inhibition
protein phosphorylates T161 on Cdc2
CDK Activating Kinase
protein phosphatase removes phosphate group from Cdc2/Cdk
Cdc25
Cdc25 removes phosphate group from:
Y15
diagram CLN1 regulation of G1 cyclins
