cell molec

Question 1

what is the function of the SER

Answer 1

1. storage and sythesis of trigylcerides
2. storage of calcium
3. storage of glycogen
4. syntheisis of steriod hormones
5. synthesis of PL and cholesterol

Question 2

what is the role of the RER

Answer 2

1. protein folding
2. detoxification - cytochromes in the liver exogenous steroids
3. storage
4. transport

Question 3

what is the role of the golgi body

Answer 3

1. renewal of the membrane
2. modification and packaging
3. delivery to organelles
   5- 6 cisternea
   cis and trans face
   cisternal maturation or vesicles transport models

Question 4

what is the function of the ECM

Answer 4

1. migration
2. cell shape and integrity
   3.proliferation
   4, differenciation

Question 5

what is the function of CT

Answer 5

1. connects
2. binds
3. supports
4. seperates
5. storage
6. repair
   7, transport
7. protects

Question 6

what are the coat proteins

Answer 6

COP11; from the ER to the golgi
COPI; returns ER export machinery
clathrin; endocytosis to early endosome - dyamin requires and an adaptor protein to link clathrin to cargo - triskellia formation 3 light, 3 heavy chains, polymerise into a lattice (in vitro)

Question 7

what are the routes of exocytosis

Answer 7

1. signal mediated diversion to lysosomes
2. signal mediated diverision to secetory granules for regulated secretion
3. constitutive secretory pathway in non polarised cells

Question 8

what are the routes of endocytosis

Answer 8

1. degredation into intraluminal vesciles - late endosome
2. storage
3. transcytosis - recycling

Question 9

cholesterol endoystosis

Answer 9

LDL receptors concentrate iin clathrin coated pits 
LDL binds to receptor 
endoystosi 
adaptor protein - Ap2 
uncoatin (clathrin) fusion with early endosome 
low PH causes disacoithiation 
receptor transported back to membrane
LDL fuses with late endosome 
hydolyitc break down into cholestorel.

Question 10

macropinocytosis

Answer 10

cell drinking - cancer cells

Question 11

phagocytsosis

Answer 11

large particles
ruffles pseudopods fuse
macrophage and red blood cells, yeast and dictostelim

Question 12

inflam

Answer 12

protective, innate response to inflammation or damage