Causes
HPV = E-6 and E7 proteins
Risk factors
Smoking, HIV, chlamydia, and poor diet
Detection when?
Three years after sex or at 21 years old
Symptoms
Unusual bleeding, pain, no symptoms
Surgery
Cryosurgery, laser surgery, conization
Surgeries
Hysterectomy, radical hysterectomy, radical trachelectomy, pelvic exenteration
Radical trachelectomy
1A +1 B, cervix + vagina, not uterus, fertility preserved
Pelvic exenteration
Radical hysterectomy + LN, bladder, vagina, colon removed
Chemo
5-FU is used
Treatment by stage
0 & IA = TAH + vaginal cuff
IA 2 =TAH or brachy if inoperable
Ib & IIB = surgery + rt
IIB & IIIa & IVa = rt + chemo
Advantages of remote afterloading units
1) Reduction of exposure to staff
2) Consistent and reproducible
3) Short treatment times
Disadvantages to remote after loading units
1) Expensive
2) Shielding required
3) Scheduling issues
What is intracavitary therapy used for
Uterine, cervix, vaginal cancers
Pushes vaginal walls out of the way to insert tube
