1
Q
What is combinatorial chemistry?
A
Used to prepare sets of compounds from sets of building blocks.
2
Q
Advantages of solid phase (5).
A
Product is immobolized.
Simple filtration for isolation.
Beads easy to manipulate (divide easily).
No side products.
Automation.
3
Q
Disadvantage of solid phase (4).
A
Hard to monitor.
Inefficient (need excess reagent).
Most reactions developed for solution phase.
Need design of linker molecules
4
Q
Advantages of solution phase (5).
A
Easy to monitor.
Scalable.
Little development time needed.
Stoichiometric reagents.
Automation.
5
Q
Disadvantage of solution phase.
A
Purification.
Automation difficult!
Medicinal Chemistry
flashcards
Decks in class (13)
# Cards
-
Introduction16
-
Drug Targets Ch 136
-
Proteins as Drug Targets Ch 29
-
Enzymes as Drug Targets Ch 3 & 723
-
Amino Acids20
-
Receptors Ch 5 & 832
-
Nucleic acids as Drug Targets Ch 6 & 926
-
Pharmacokinetics Ch 1127
-
Drug Discovery: Finding a Lead Ch 1211
-
From target to market7
-
McLaughlin- New Approach2
-
Ch 17 Computational3
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Ch. 15 Combinatorial5
