CH 18 Flashcards

(70 cards)

1
Q

What type of tissue is blood?

A

Blood is a continuously regenerated connective tissue.

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2
Q

What are the main functions of blood?

A

Transportation, protection, and regulation.

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3
Q

What does blood transport?

A

Oxygen, carbon dioxide, nutrients, hormones, heat, waste products, formed elements, dissolved molecules, and ions.

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4
Q

How does blood protect the body?

A

Leukocytes and plasma proteins defend against pathogens; platelets and clotting proteins prevent blood loss.

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5
Q

How does blood regulate body conditions?

A

Maintains body temperature, pH (7.35–7.45), and fluid balance.

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6
Q

What is the average adult blood volume?

A

About 5 liters (range 4–6 L).

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7
Q

How does oxygenation affect blood color?

A

Oxygen-rich blood is bright red; oxygen-poor blood is dark red.

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8
Q

What is blood viscosity compared to water?

A

Blood is 4–5 times thicker than water.

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9
Q

What increases blood viscosity?

A

Increased erythrocyte number or decreased plasma fluid.

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10
Q

What is hematocrit?

A

The percentage of erythrocytes in blood.

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11
Q

Normal hematocrit range for males?

A

42–56%.

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12
Q

Normal hematocrit range for females?

A

38–46%.

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13
Q

What are the three formed elements of blood?

A

Erythrocytes, leukocytes, and platelets.

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14
Q

What is plasma composed of?

A

92% water, 7% plasma proteins, 1% dissolved solutes.

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15
Q

What are the main plasma proteins?

A

Albumin, globulins, fibrinogen, regulatory proteins.

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16
Q

What is the main function of albumin?

A

Maintains colloid osmotic pressure and transports substances.

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17
Q

What are gamma globulins?

A

Immunoglobulins (antibodies).

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18
Q

What is fibrinogen’s function?

A

Converted to fibrin to form blood clots.

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19
Q

What is serum?

A

Plasma without clotting proteins.

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20
Q

What is the structure of erythrocytes?

A

Small, flexible, biconcave discs without nucleus or organelles.

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21
Q

What is hemoglobin made of?

A

Four globin chains (2 alpha, 2 beta), each with a heme group containing iron.

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22
Q

How many oxygen molecules can one hemoglobin bind?

A

Four.

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23
Q

Where does oxygen bind on hemoglobin?

A

To the iron ion in the heme group.

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24
Q

Where does carbon dioxide bind on hemoglobin?

A

To the globin protein.

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25
What hormone controls erythrocyte production?
Erythropoietin (EPO).
26
Where is EPO produced?
Primarily in the kidneys.
27
What stimulates EPO production?
Low blood oxygen levels.
28
How long do erythrocytes live?
About 120 days.
29
Where are old erythrocytes destroyed?
Spleen or liver.
30
What transports iron in the blood?
Transferrin.
31
What is anemia?
Reduced erythrocyte percentage or reduced oxygen-carrying capacity.
32
Common symptoms of anemia?
Lethargy, shortness of breath, pallor, palpitations.
33
What determines ABO blood type?
Presence or absence of A and B antigens on erythrocytes.
34
What antigens are present in Type A blood?
A antigen only.
35
What antigens are present in Type B blood?
B antigen only.
36
What antigens are present in Type AB blood?
Both A and B antigens.
37
What antigens are present in Type O blood?
Neither A nor B antigens.
38
Why don’t people form antibodies against their own blood type?
The immune system recognizes their own antigens as self.
39
What determines Rh positive or negative blood type?
Presence or absence of antigen D (Rh factor).
40
When do anti-D antibodies form?
After exposure to Rh-positive blood.
41
What is agglutination?
Clumping of erythrocytes due to antibody binding.
42
What can agglutination cause?
Blocked vessels, hemolysis, organ damage.
43
What is hemolytic disease of the newborn?
Destruction of fetal RBCs when Rh-negative mother produces anti-D antibodies against Rh-positive fetus.
44
What are the two leukocyte classes?
Granulocytes and agranulocytes.
45
Which leukocytes are granulocytes?
Neutrophils, eosinophils, basophils.
46
Which leukocytes are agranulocytes?
Monocytes and lymphocytes.
47
Most numerous leukocyte?
Neutrophils.
48
Which leukocytes increase during bacterial infection?
Neutrophils.
49
Which leukocytes fight parasitic worms?
Eosinophils.
50
Which leukocytes release histamine and heparin?
Basophils.
51
What do monocytes become in tissues?
Macrophages.
52
What do T lymphocytes do?
Manage immune response.
53
What do B lymphocytes do?
Produce antibodies.
54
What do NK cells do?
Kill abnormal or infected cells.
55
What is leukopenia?
Reduced leukocyte count.
56
What is leukocytosis?
Elevated leukocyte count.
57
What are platelets?
Small cell fragments from megakaryocytes involved in clotting.
58
Normal platelet count?
150,000–400,000 per cubic millimeter.
59
What are the three phases of hemostasis?
Vascular spasm, platelet plug formation, coagulation.
60
What happens during vascular spasm?
Vasoconstriction reduces blood loss.
61
What happens during platelet plug formation?
Platelets adhere to exposed collagen and aggregate.
62
What happens during coagulation?
Fibrin mesh forms from fibrinogen to stabilize clot.
63
What is required for clotting?
Calcium, clotting factors, platelets, vitamin K.
64
Which clotting factors require vitamin K?
Factors II, VII, IX, and X.
65
What is a thrombus?
A clot inside a blood vessel.
66
What is an embolus?
A dislodged clot traveling in bloodstream.
67
What is a pulmonary embolism?
A clot lodged in the lungs.
68
What is hemophilia?
X-linked recessive clotting disorder due to missing clotting factor.
69
What is thrombocytopenia?
Platelet deficiency.
70
What increases risk of hypercoagulation?
Birth control pills, prolonged inactivity, genetic factors.