O (open form)
nucleotides can bind to or be released from ß subunit
L(loose form)
nucleotides are trapped in ß subunit
T(tight)
ATP is synthesized from ADP and Pi
nonshivering thermogenesis
if electron transport is uncouple from ATP synthesis, heat is generated
how electron transport is uncoupled tap synthesis
uncoupling by protein 1 (thermogenic)(from inner mitochondrial membrane) in brown fat
oligomycin
inhibition of atp synthase (by inhibiting Fo
DNP and thermogenin
uncoupling of phosphorylation from electron transport
Hydrophobic proton carrier, forms proton conducting pores
Bongkretic acid
atracetyloside
inhibition of ATP-ADP exchange(inhibits adenine nucleotide exchange)