Ch 3

Question 1

What are the possible uptake & elimination routes for an organisms (6)

Answer 1

1. Water
2. Food
3. Dermal uptake
4. Loss from gills
5. Biotransformation
6. Loss in urine & feces

Question 2

What is the black box approach ?

Answer 2

a mathematical model that can model the process of intake & uptake of an organism.

Question 3

What assumptions have to be made with the black box ?

Answer 3

1. must assume that only one method of uptake & elimination is dominant.
2. both uptake & elimination happen in one compartment
3. for some systems the entire organism may represent a compartment
4. animals are often represented as a three compartment system.
5. each of the transitions between the compartments will have rate constants
6. compartment is instantly & homogeneously mixed
7. kinetics & rate coefficients are constant over time.
8. No biotransformation or organism effects take place in this compartment

Question 4

What are the 3 compartments which animals are made up of

Answer 4

1. Fat storage
2. Blood
3. Liver