Etiology
Study of causes for phenomena
Idiopathic
Cause is unknown
Iatrogenic
Treatment/medically caused
Maybe better than nothing
Risk factor
A factor that when present increases the likelihood of disease
Pathogensis
Disease life story
Clinical manifestations
Signs
Symptoms
Symptom
Subjective feeling of abnormality in the body
Sign
Objective or observed manifestation of disease
Stages and clinical course
Latent period Prodromal period Latent period Subclinical stage Acute clinical course Chronic clinical course Exacerbation Remission Convalescence Sequels
Latent period
Time between exposure and first appearance of S/S
(Remission/relapse) period where S/S of an illness become mild/silent
I.e. Gout, TB
Prodromal period
First Appearance of S/S of disease
Subclinical stage
Not shown clinical S/S yet
pt fxn norm, dis well establish
Acute Clinical course
Severe, happens fast
Chronic clinical course
Mild, long time
Exacerbation
Getting worse
Remission
Decrease in severity, S/S
May indicate dis is cured
Convalescence
Recovery stage
Sequela
(Consequences) from an illness
Concepts of Normality in health and disease
Average range of values
Bell curve
Something bad happens if out of range ⬆️⬇️
95% of value = normal
Statistical normality
Estimate of diseases in a normal population
Bell curve
Reliability
Consistency
Test’s ability to give same results in repeated measurements
0.5% +/-
Validity
How accurate they are in reading
Predictive value
Percent you can predict
Testing first treatment last
Sensitivity
Test is sensitive not specific
Probability that the test will be positive when applied to a person with a particular condition
I.e. TB