1
Q
Cells that produce TNFa
A
Major source activated M1 macrophages
2
Q
proinflammatory cytokines
A
TNF-a
IL-1a
IL-1B
IL-6
Chemokines (chemotactic cytokines)
3
Q
anti-inflammatory cytokines
A
IL-4
IL-10
IL-13
4
Q
What is TNF-alpha
A
membrane bound surface protein cleaved by metalloproteases that is released in soluble form and a pro inflammatory cytokine
5
Q
What about TNF- A in humans
A
Commercially available anti-TNF monoclonal antibodies and recombinant TNF soluble receptors have proven efficacious in human patients with Crohn’s disease and rheumatoid arthritis
6
Q
What are the effects of inhibiting TNF-a
A
Recrudescense of pulmonary mycobacterial infections and infectious complications after ortho surgery
ACVS Phase 1
flashcards
Decks in class (71)
# Cards
-
Chapter 1 Inflammatory Response6
-
Chapter 3 Stem cells and Regenerative Medicine7
-
Chapter 4 PRP/ 5 Fluid therapy8
-
Chapter 6 Shock15
-
Chapter 7 Bleeding and Hemostasis32
-
Chapter 8 Metabolism and Nutritional needs1
-
Chapter 9 Wound Healing43
-
Chapter 10 Wound Infections and Antimicrobial Use8
-
Chapter 11 Sterilization28
-
Chapter 12 Instrumentation10
-
Chapter 13 The Operating Room10
-
Chapter 15 Electrosurgery and Laser Applications10
-
Chapter 16 Suture material, tissue staplers, ligation devices, and closure methods12
-
Chapter 17 Instrument and Tissue Handling Techniques3
-
Chapter 18 Surgical Hemostasis23
-
Chapter 21 Anesthesia Principles and Monitoring39
-
Anethestic Drugs69
-
Nerve Blocks13
-
Chapter 22 Anesthesia Practice for Existing Conditions15
-
Chapter 23 Fundamentals of interventional radiology and interventional endoscopy1
-
Chapter 24 Fundamentals of Laparoscopy and Thoracoscopy9
-
Chapter 25 Introduction to Oncologic Surgery for the General Surgeon3
-
Chapter 28: Imaging of the Neurologic System1
-
Chapter 29 Pathogenesis and Physiology of CNS Disease and Injury10
-
Chapter 38 Tissues of the Musculoskeletal System20
-
Chapter 39 Bone Biomechanics and Fracture Biology29
-
Chapter 40 Open Fractures1
-
Chapter 41 Internal Fracture Fixation29
-
Chapter 45 Delayed Unions, Nonunions, and Malunions12
-
Chapter 47 Osteomyelitis and Implant-Associated Infections7
-
Chapter 48 Bone Grafts and Substitutions11
-
Chapter 68 Arthritis15
-
Chapter 70 Muscle and Tendon Disorders4
-
Chapter 71 Arthroscopy2
-
Chapter 73 Osteochondrosis1
-
Chapter 75 Primary Wound Closure10
-
Chapter 76 Open Wounds17
-
Chapter 81 Burns4
-
Chapter 83 Spleen2
-
Chapter 86 Peritoneum and Retroperitoneum2
-
Chapter 87 Soft Tissues of the Oral Cavity10
-
Chapter 88 Salivary Glands1
-
Chapter 90 Esophagus6
-
Chapter 91 Stomach12
-
Chapter 92 Small Intestine7
-
Chapter 93 Colon15
-
Chapter 94 Rectum, Anus, and Perineum7
-
Chapter 95 Liver and Biliary System7
-
Chapter 97 Pancreas9
-
Chapter 99 Nasal Planum, Nasal Cavity, and Sinuses1
-
Chapter 101 Larynx16
-
Chapter 102 Trachea and Bronchi2
-
Chapter 103 Lungs25
-
Chapter 105 Thoracic Cavity16
-
Chapter 106 Cardiac Surgery7
-
Chapter 107 Pericardial Surgery7
-
Chapter 108 Vascular Surgery1
-
Chapter 109 Ovaries and Uterus4
-
Chapter 110 Vagina, Vestibule, and Vulva1
-
Chapter 113 Prostate5
-
Chapter 114 Kidneys1
-
Chapter 115 Ureters2
-
Chapter 116 Bladder7
-
Chapter 118 Sphincter Mechanism Incontinence1
-
Chapter 120 Adrenal Glands4
-
Chapter 121 Thyroid and Parathyroid Glands10
-
Chapter 122 Pinna and External Ear Canal6
-
Chapter 123 Middle and Inner Ear1
-
Antibiotics25
-
Anatomy47
-
Miscellaneous20
