What are the functions of skin?
IS IT PUS?
I nfection S ensation I mmunological surveillance T emp regulation P revent fluid loss U V protection S tructural barrier
What are the layers of the epidermis?
Colin Likes Grilled Spicy Beef
Stratum
1. Corneum - dead keratinized cells
2. Lucidum - clear layer of dead cells (glaborous)
3. Granulosum - mature keratinocytes, protein synthesis
4. Spinosum - prickle cell layer - keratinocytes produce keratin - SCC orig
5. Basale - proliferating layer, contains melanocytes - BCC originates here
What cells are found in the epidermis?
Keratinocytes → predominant cell type
Langerhans cells → immune system → antigen presenting cells
Merkel cells → mechanoreceptors of neural crest origin
Melanocytes → from neural crest, in stratum germinativum, produce melanin.
What are the layers of the dermis and what are they comprised of?
95% thickness of skin
Papillary - superficial → finer collagen fibres, more cells
Reticular - deep → coarser collagen, less cells
1-3 produced by fibroblasts
What are the skin appendages?
Hair follicles - inner & outer root sheath, anagen (growth 75%) telogen (resting) phases Eccrine glands (sweat, odourless, secrete by exocytosis) Apocrine glands (axilla, groin, thicker secretions, body odour, hidradenitis suppurativa → infection Sebaceous glands - holocrine glands, drain into pilosebaceous units
What do these histological terms mean? Acanthosis Papillomatosis Hyperkeratosis Parakeratosis
What is the blood supply to the skin?
Deep vessels (aorta → trunk, limbs, H&N)
Interconnecting vessels
Plexuses - anastomoses b/t cutaneous arteries
What is a perforator?
What is the difference b/t a true anastomosis and choke vessel?
Perforator = direct branch from system of A&Vs whose primary function is to perfuse the deeper structures, muscles and bones
True anastomosis = no change in calibre
Choke vessel = reduced calibre vessels which dilate to restore blood flow to an area of ischaemia
What is an angiosome?
An angiosome is a composite block of tissue supplied by a named artery & its venae comitantes
adjacent angiosomes are connected by true anastomoses or choke vessels
junctional zones tend to occur within a muscle
Who described angiosomes and who extended the work?
What are the characteristics of arteries?
Manchot 1889
Salmon 1930s
Taylor and Palmer BJPS 1987
Arterial Characteristics (Taylor)
Vessels
- travel with nerves
- obey law of equilibrium (if sources vessel is small, adjacent source vessel is large)
- travel from fixed to mobile tissue
- have a fixed destination but varied origin
- size and orientation is a product of growth.
What is the anatomical, dynamic and potential territories of flaps?
Anatomical Territory = area in which the vessel branches ramify before anastomosing with adjacent vessels. (choke vessels join these anatomical areas together)
Dynamic Territory = area which staining extends into after IV fluorescein – via choke vessels.
Potential Territory = area that can be included in a flap if it is delayed
e.g. TRAM: zone 1 = anatomical, 2&3 = dynamic, 4 = potential
What is the delay phenomenon?
Delay = expansion of the vascular territory of a flap to achieve its potential vascular territory
Conditions flap to survive with reduced blood flow
e.g. pedicled TRAMs - DIEP divided 2/52 before, forehead flap
What is the possible mechanism of delay phenomenon? THAIS!
Unifying theory - all of above! (Pearl 1981)
Describe the microcirculation in the skin
How is blood flow controlled?
What is the blood supply of the head and neck skin?
Below zygomatic arch (mainly dermal subdermal)
Above zygomatic arch - supraorbital - supratrochear - sup temporal vessels b/t skin & galea
Neck
What is the blood supply of the trunk skin?
Perforators - emerge from muscle / aponeurosis and run in sup fascia
Segmental intercostals - ant, lat, post
Chest - ant & lat ic (deltopectoral flap)
Back - post ic perforators, circumflex scapula branches (scapular flaps), muscle perforators (LD, pec major, trapezius)
sup circ iliac - groin flap
sup epigastric - hypogastric flap
What is the blood supply of the upper limb skin?
Forearm - prefascial & subfascial plexuses, supplied by septocutaneous perforators
Upper arm
- posterior descending br of profunda brachii - runs in lateral intermuscular septum (attached to humerus, separates BR (dist) and Biceps (prox) from triceps)
Forearm
What is the blood supply of the lower limb skin?
Ant tibial perforators → row along ant border / subcut surface of tibia b/t anterior tibial muscles & peroneal compartment.
Peroneal perforators → b/t peroneal and post compartments.
Posterior tibial branches → in IM septum b/t FDL and Soleus emerging in a line behind post border of subcut surface of tibia, and also others pass backwards through muscles of soleus and gastroc to emerge midway b/t 2 bellies of gastroc and also midway b/t midline & lat & med margins of gastroc.
How are flaps classified?
Can be classified in 5 ways (5 C’s)
How are flaps classified by circulation?
Random
Axial
What are direct cutaneous skin flaps? Give some examples
e. g. deltopectoral (IMA perforators), groin (superficial external iliac)
Who classified fasciocutaneous flaps?
What are you are familiar with?
Type A - supplied by multiple FC perforators that enter at the base of the flap and extend throughout its longitudinal length. Can be based proximally/ distally/ as island. e.g. Ponten flap
Type B - single FC perforator & is fairly consistent. This flap may be isolated as an island flap or used as a free flap.
e.g. parascapular, scapular, some lower limb perforator flaps (?propeller)
Type C - based on multiple small perforators that run along a fascial septum. Supplying artery is included with flap. May be based proximally/ distally/ as free flap. e.g. RFF, lat arm flap
Type D is an osteomyocutaneous flap = Type C + adjacent muscle & bone. May be based proximally / distally on a pedicle / free flap e.g. RFF w radius, lat arm w humerus
Cormak and Lamberty also introduced a new classification based on clinical applications. Type A has a fascial plexus, Type B has a single perforator, and Type C has multiple perforators and a segmental source artery.
What is Mathes and Nahai’s classification of fasciocutaneous flaps?
Type A - direct cutaneous pedicle to fascia
Type B - septocutaneous perforator
Type C - w perforators from musculocutaneous source