What is an immunogenicity?
An antigen that is recognized and elicits an immune response
What is humoral immunity?
An arm of adaptation immunity
Works to eliminate extracellular antigens
Mediated by B-lymphocytes aka B-cells-WBC
Develop in bone marrow and mature there as well
Gather in secondary lymphatic organs
Goal: make antibodies to help fight infection
Immature?
Antigen-specific receptor; not developed
Naive?
Have an antigen-specific receptor (not in contact with an antigen)
Activated?
Antigen is bound to the antigen-specific receptor (cell proliferated)
Effector?
Descendants of activated lymphocytes (produce substances)
Memory?
Long-lived descendants of activated lymphocytes (that can quickly became activated)
What is an antigen?
molecule recognized as foreign by the body ( recognition by antibodies or lymphocytes)
Explain Clonal Selection and Expansion Theory.
Body is prepared for infinite amount of antibodies; since there are an infinite amount off antigens out there
MHC?
Major Histocompatibility Complex Molecules;
MHC1= any cell w/nucleus
MHC2= WBC w/ T-Helper cells
MHC3= secreted proteins
Virus removes MHC1 cells and then the cell can’t call for help; backup is NK
Natural Killer cells?
Kill cells without MHC1 molecules; backup to prevent spreading
Antibody?
Glycoproteins (immunoglobulins)
Produced by B-cells (plasma cells)
Y shaped molecules or proteins
Actually 4 chains; 2 light and 2 heavy
What are the classifications of antibodies?
IgG- most abundant in blood IgA- most abundantly produced IgM IgE IgG
Opsonization?
Signal for eating; antibodies can work as the zipper
Complement?
Helps w/ inflammation, lyse, foreign cells, and opsonization
Other three functions of antibodies?
Immobilization, Cross-Linking,
And Antibody dependent cellular cytotoxicity (ADCC)- antibodies targeting cell for NK
