Sister chromatid
Single arm of the
chromosome
Somatic Cells
Any body cell in a multicellular organism EXCEPT sex cells or gametes Ex: Neurons - Skin cells - Blood cells - Muscle cells - Internal organ cells - Bone cells - .... any body cell!
The function of cell division for somatic cells is:
Growth
Add new cells to grow the organism
Repair
If damage occurs, the cells must replace
Maintenance
Cells must be replaced as they wear out
In a human somatic cell:
23 pairs of chromosomes
⇒ 22 pairs of autosomes (homologous chromosomes) ⇒ 1 pair of sex chromosomes: X and Y
Homologous chromosomes
Each parent provides the same 22 chromosomes, which code
for the same genes at the same locations (may have different versions of the trait - ALLELES)
Non-homologous chromosomes
Only X and Y (have different genes)
For cell division to occur, genetic material is duplicated and passed from original called to each new cell called
PARENT CELL
DAUGHTER CELLS
Male
XY
Female
XX
Ploidy
Number of sets of each chromosome
Diploid
Chromosomes in pairs (2n)
Human Somatic Cell: 23 pairs = 46 cs
Haploid
Set of unpaired chromosomes (n)
Human gamete cell: 23 cs
Polyploid
More than 2 of each homologous chromosome (3n, 4n, 6n)
Not in human cells
Human Karyotype
Stages of the Cell Cycle
Interphase (growth and metabolism) ○ G1 phase ○ S phase (DNA REPLICATION) ○ G2 phase Cell division ○ Mitosis (dividing genetic material) ○ Cytokinesis (dividing cytoplasm)
Interphase
G1
After S phase
Unreplicated chromosomes have a single ‘arm’
Unreplicated chromosomes have a single ‘arm’
Replicated chromosomes have sister chromatids
PROPHASE
Phases of Mitosis
METAPHASE
Phases of Mitosis
Spindle fibres attach to centromere of each chromosome and guide them to align along the equator of the cell
ANAPHASE
Phases of Mitosis
Centromere splits and sister chromatids are pulled to opposite poles
TELOPHASE (& CYTOKINESIS)
Phases of Mitosis
Cytokinesis in animal & plant cells
Animal cells form a cleavage furrow (contracted indent) and then separate
Plant cells have a cell well so a cell plate forms between the two daughter cells
Regulation of the cell cycle
n order for organisms to remain healthy, its cells must only divide at certain times.
Cells have START and STOP signals for cell division.
When these regulatory signals are not present (usually due to mutation) we get CANCER
How are sex cells different from somatic cells?
Recombination of Genes
This happens in gametes in two ways: