Chapter 17 Immune Modulators

Question 1

Immune modulator

Answer 1

Fingolimod (Gilenya)

Question 2

Fingolimod (Gilenya) MOA

Answer 2

Traps lymphocytes in lymph nodes, which suppresses immune-mediated inflammation

Question 3

Fingolimod (Gilenya) Indications

Answer 3

-Relapsing MS, Autoimmune diseases (psoriasis & transplant rejections)

Question 4

Fingolimod (Gilenya) AE

Answer 4

-Bradycardia
-Increase risk of infection
-Macular Edema
-Elevated liver enzymes

Question 5

T & B Cell suppressors prototypes (three)

Answer 5

Azathioprine (imuran), Cyclosporine (sandimmune), & Methyleprednisone

Question 6

Azathioprine (imuran) & Cyclosporine (sandimmune) Indications

Answer 6

Prevention of specific transplant rejections & some autoimmune conditions

Question 7

Methylprednisone MOA & Indication

Answer 7

Inhibits all stages of T-cell activation
* Induction/maintenance of immunosuppression
* Used for acute rejection

Question 8

Interleukin receptor Antagonist

Answer 8

Anakinra Kineret

Question 9

Anakinra Kineret Action

Answer 9

Decrease inflammation, swelling, and joint pain associated with auto immune conditions

Question 10

Monoclonal Antibodies Prototype

Answer 10

Bavacizumab (avastin)

Question 11

Bavacizumab (avastin) TE

Answer 11

Reduce tumor vascularization (Angiogenesis)

Question 12

Bavacizumab (avastin) Route of adminstration

Answer 12

Most are injected medication because they are rapidly broken down in the GI tract