Robbins Pathology- Endocrine (Chapter 24) > Chapter 24- Thyroid > Flashcards

Chapter 24- Thyroid Flashcards

(76 cards)

Study These Flashcards
1
Q

Effects of T3/T4 on the liver

A
  • Increased cholesterol synthesis
  • Increased cholesterol reabsorption from plasma
  • Conversion of cholesterol to bile acids
  • increased fat oxidation/synthesis
  • Increased gluconeogenesis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the affect of T3/T4 on muscle

A
  • Increased protein catabolism
  • Increased glucose utilization
  • Increased fat oxidation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Where is thyroglobulin synthesized and stored

A

Synthesized and stored in the colloid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the most common cause of hyperthyroidism

A

Primary hyperthyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What type of condition does diffuse hyperplasia fall into

A

Aka Graves’ disease

-Hyperthyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What type of condition does hyper functioning multinodular goiter fall into

A

Hyperthyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What type of condition does hyperfunctioning thyroid adenoma fall into

A

Primary hyperthyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What type of condition does pituitary adenoma fall under

A

Secondary hyperthyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IN the cause of suspected hyperthyroidism, which condition is suspected when the TSH level is low

A

Primary hyperthyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

IN the cause of suspected hyperthyroidism, which condition is suspected when the TSH level is high

A

Secondary hyperthyroidism, so basically pituitary adenoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the four components of thyroid storm

A
  • Fever
  • Cardiac manifestations
  • GI symptoms
  • Precipitating history (drugs, pregnancy)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

During thyroid storm, what are the cardiac manifestations that can be seen

A
  • Tachycardia

- CHF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

During thyroid storm, what are the GI symptoms that can be seen

A
  • Diarrhea

- Jaundice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

During thyroid storm, what are the past history factors that can contribute

A
  • Pregnancy/postpartum
  • Hemithyroidectomy
  • Drugs, such as amiodarone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the treatments for the manifestations seen in thyroid storm

A
  • Beta blockers (for cardiac)

- NSAIDs (for the fever)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the Wolf-Chaikoff effect

A

High doses of iodide will decrease the amount of thyroid production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the most common cause of hyperthyroidism

A

Graves disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the clinical manifestations of Graves disease

A

1- Hyperthyroidism with gland enlargement
2- Infiltrative ophthalmopathy
3- Pretibial myxedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the histological findings in the case of thyroid gland enlargement

A

Resorption follicles, which are basically just the hyper collection of the thyroid products

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the cause of ophthalmopathy in Graves

A

1) Lymphocytes invade the preorbital space
2) Fibroblasts have TSH receptor, so are stimulated by TSHR Abs
3) Extraocular muscles swell
4) Hyloranadate and proteoglycans accumulates (aka matrix accumulation)
5) Adipocytes expand and fill space behind eyes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is pretibial myxedema and what is it indicative for

A

-Infiltrative dermopathy causing scaly indurated skin on the shin area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are the serum laboratory findings of TSH, T3/T4, TSI in the case of Graves

A
  • T3/T4 high
  • TSH low
  • TSI high (thyroid stimulating Ig)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What are the clinical presentations of congenital hypothyroidism

A

Aka cretinism, from lack of thyroid:

  • Mental retardation
  • Growth retardation
  • Course facial features
  • Umbilical hernias
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are the genetic components that can cause congenital hypothyroidism

A
  • PAX8, FOXE1, TSH receptor mutations all cause defects in thyroid development
  • THRB mutations cause thyroid hormone resistance syndrome
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What are the clinical skin findings in the case of hypothyroidism
Skin is: - Course (follicular keratosis) - Cool - Dry - yellowish (carotenemia)
26
What is the most common cause of hypothyroidism
Hashimoto thyroiditis
27
What is the pathogenesis of Hashimoto thyroiditis
-Autoantibodies against thyroglobulin and thyroid peroxidase
28
What is the process of Hashimoto hyroiditis causing hypothyroidism
1) Immune mediated insult 2) Hyperactivity and enlargement 3) Follicular cell exhaustion
29
What are the histological changes seen in Hashimoto thyroiditis
- Lymphcytic infiltrate appearance with germinal centers | - Hurthle cell metaplasia, where there are strophic follicule cells with eosinophilic changes
30
Which antibodies are present in Hashimoto thyroiditis
- antithyroglobulin AB aka hTg-Ab (80-90%) | - Antiperoxidase antibody aka hTPO-Ab (90-100%)
31
Which antibody is present in Graves
Anti TSH receptor antibody (TSHR-AB or TSI) (80-95%)
32
What is granulomatous thyroiditis
Aka DeQuervain’s thyroiditis | -Painful, Granulomatosis condition
33
What is the pathogenesis of Granulomatous thyroiditis
-Unknown, maybe viral
34
What are the characteristics of Riddle thyroiditis
Fibrosing process that extending from the thyroid into the adjacent tissue ****Feels like cement, or wood, so it is very hard and sticks
35
What are the histological features of Riddle thyroiditis
-Fibrosis, with lymphocytes and plasma cells*** (these are secreting IgG4)
36
What is the antibody present in Riddle thyroiditis
IgG4
37
What are some of the IgG4 conditions
- Riddle thyroiditis - Salicary gland - Autoimmune pancreatitis*** - Inflammatory pseudotumors - Sclerosing mediastinitis*** - Idiopathic retroperitoneal fibrosis *** - Inflammatory aortic aneurysm
38
What is the cause of a diffuse nontoxic goiter
Diffuse aka non-modular - Iodine deficiency - Goitrogens (cassava root) - Brassicaceae (uncooked broccoli, cauliflower, cabbage, radish)
39
How are most diffuse goiter found
Mass effect causing: - Dysphagia - Hoarseness - Stridor - Superior vena cava syndrome
40
What ages do diffuse goiter tend to occur
15-25
41
What age do nodular goiters occur
>26
42
Cold thyroid nodules tend to be which type
benign, but higher Neoplastic chance than hot nodules
43
What is the conformation process of a cold nodule
Ultrasound and fine needle biopsy
44
What is the process of testing what should be done with a thyroid nodule
1) TSH test 2) If low TSH and hot nodule, needs to be removed 3) if low TSH and cold nodule, then needs a fine needle aspiration and ultrasound
45
What are the benign thyroid nodules
- Hyperplastic (adenomatous nodules) | - Follicular adenomas
46
What are the malignant thyroid nodules
- Papillary thyroid carcinoma - Follicular cell carcinoma - Anaplastic carcinoma - Medullary carcinoma
47
What is the prognosis and characteristic of Follicular adenomas
Benign tumor that: - Clonal population of follicular cells with thyroid autonomy - Intact cause or nuclear features
48
What is the prognosis and histological features of papillary thyroid carcinoma
Malignant tumor with various features but all have: - Orphan Annie Eyes: - Papillary architecture - Psammoma bodies
49
What determines the prognosis of the papillary thyroid carcinoma
The age, with < 55 being more promising than older
50
What are the histological features of follicle variant of papillary thyroid carcinoma
-Follicular architecture but the nuclear features of papillary carcinoma
51
Follicular variant of papillary carcinoma tends to have which mutation
RAS
52
What is the prognosis of a tall cell variant of papillary carcinoma
-Seen in older patients and is very aggressive
53
The diffuse sclerosing variant of papillary carcinoma is commonly seen in which population
Children and young adults
54
The diffuse sclerosing variant of papillary carcinoma show which characteristics
- Greater incidences of distant metastasis | - Shorter periods of disease free survival
55
What are the locations that the diffuse sclerosing variation of papillary carcinoma metastasize to
Lung ** Brain Bone Liver
56
Which form of papillary carcinoma has the most favorable outcome
Diffuse sclerosing form (mostly because they occur in younger ages)
57
What are the characteristics of follicular carcinoma
Invasive properties
58
Where are follicular carcinomas normally seen
Areas where there are goiters from iodide deficiency
59
What are the histological findings of follicular carcinoma
- Invasion of the capsule gives a mushroom appearance | - Invasion of the blood vessels leading to hematogenous metastasis
60
What is the significance of the invasion characteristic of follicular carcinoma
Spreads to the vasculature, so there is much more hematogenous metastasis
61
What are the the histological patterns seen in anaplastic thyroid carcinoma
Shows areas of papillary carcinoma with well defined border mixed with areas of a high grade tumors
62
What is the prognosis of anaplastic carcinoma
- Seen in older patients and is Highly aggressive | - Presents with mass effect and die within a year
63
What are the gene mutations seen in papillary carcinomas
Gain of Functions: - RET/PTC (tyrosine kinase activity) - BRAF (map kinase signaling)
64
What is the gene mutation in Follicular carcinomas
-PAX8-PPARG
65
What are the gene mutations in anaplastic carcinoma
TP53
66
What is the function of the C cells in the thyroid
-Release calcitonin
67
What are the histological cells found in a normal thyroid
- C cells | - Follicular cells
68
Medullary carcinomas of the thyroid are composed of which cells
C cells
69
What are the histological findings in medullary carcinoma
- Neuroendocrine carcinoma from C cells - Blue cells that show dispersed chromatin - Amyloid - C cell hyperplasia
70
What is the staining that can be used to see medullary carcinomas
-Congo red stain, as there is amyloid deposition in the thyroid in this carcinoma
71
What form of medullary carcinomas are most common
Sporadic forms
72
What are the characteristics of sporadic medullary carcinomas
- Unification tumors - Seen in age of 50 - Agressive
73
What determines the grade a medullary carcinoma and the survival rate
-The rate of metastasis and LN involvment
74
What form of medullary carcinoma shows the most favorable outcome
Familial (100% 15 year survival)
75
What is the gene mutation seen in medullary carcinomas
RET
76
What are the three most common causes of hyperthyroidism
- Graves leading to diffuse hyperplasia - hyper-functional multinodular goiter - Hyperfunctional thyroid adenoma
Robbins Pathology- Endocrine (Chapter 24)
flashcards
Decks in class (5)
# Cards
Brainscape helps you reach your goals faster, through stronger study habits.
© 2026 Bold Learning Solutions. Terms and Conditions