Chapter 3: Data Interpretation

Question 1

Causes of anaemia (categorised by MCV)

Answer 1

Red blood cells:

• Microcytic (low MCV) = iron deficiency anaemia, thalassaemia, sideroblastic anaemia.
• Normocytic (normal MCV) = anaemia of chronic disease, acute blood loss, haemolytic anaemia, renal failure (chronic).
• Macrocytic (high MCV) = B12/folate deficiency (megaloblastic anaemia), excess alcohol, liver disease (including non-alcoholic causes), hypothyroidism, “M” haematological causes (myeloproliferative, myelodysplastic, multiple myeloma).
  
  • B12 deficiency includes pernicious anaemia.

Question 2

Causes of neutrophilia

Answer 2

Neutrophilia (high) :

• bacterial infection
• tissue damage (inflammation/infarct/malignancy)
• *steroids*.

Question 3

Causes of Neutropenia

Answer 3

Neutropenia (low neutrophils)

• viral infection
• chemotherapy/radiotherapy (may become neutropenic in response to infection, neutropenic sepsis)
  
  • If neutropenic sepsis, must give urgent IV broad-spectrum antibiotics (hospital-specific).
• clozapine (antipsychotic)
• carbimazole (antithyroid).

Question 4

Causes of lymphocytosis

Answer 4

Lymphocytosis (high lymphocyts)

• viral infection
• lymphoma
• CLL.

Question 5

Causes of Thrombocytopenia

Answer 5

Thrombocytopenia (low platelets)

• reduced production
  
  • viral infection
  • drugs especially penicillamine in RA
  • myelodysplasia, myelofibrosis, myeloma
• increased destruction
  
  • heparin
  • hypersplenism
  • DIC
  • ITP
  • HUS/TTP

Question 6

Causes of thombocytosis

Answer 6

Thrombocytosis (high platelets)

• reactive
  
  • bleeding
  • tissue damage e.g. infection/inflammation/malignancy
  • post-splenectomy
• primary
  
  • myeloproliferative disorders

Question 7

Causes of hyponatraemia

Na+ 135-145 mmol/L

Answer 7

Hyponatraemia: assess fluid status first.

• Hypovolaemic
  
  • fluid loss (D&V)
  • Addison’s
  • any diuretic.
• Euvolaemic
  
  • SIADH
    
    • small cell lung tumours, _i_nfection, abscess, drugs (carbamazepine + antipsychotics), head injury.
  • psychogenic polydipsia
  • hypothyroidism.
• Hypervolaemic
  
  • heart failure
  • renal failure
  • liver failure (hypoalbuminaemia)
  • nutritional failure (hypoalbuminaemia)
  • thyroid failure (hypothyroidism – can be euvolaemic too).

Question 8

Causes of SIADH

Answer 8

SIADH

• small cell lung tumours
• infection
• abscess
• drugs (carbamazepine + antipsychotics)
• head injury.

Question 9

Causes of Hypernatraemia

Answer 9

Hypernatraemia: Causes all begin with “D”…

• Dehydration.
• Drips i.e. too much IV saline.
• Drugs e.g. effervescent tablet preparations or IV preparations with high Na+ content.
• Diabetes insipidus – opposite of SIADH.

Question 10

Causes of Hypokalaemia (3.5-5mmol/L)

Answer 10

Hypokalaemia: DIRE

• drugs (loop + thiazide diuretics)
• inadequate intake or intestinal loss (D&V)
• renal tubular acidosis
• endocrine (Cushing’s + Conn’s syndrome).

Question 11

Causes of Hyperkalaemia (3.5-5mmol/L)

Answer 11

Hyperkalaemia: DREAD

• drugs (K+-sparing diuretics + ACE-i) [& ARBS]
• renal failure
• endocrine (Addison’s disease)
• artefact (clotted sample)
• DKA (when insulin given to treat DKA, K+ drops so needs monitoring + replacement).

Question 12

Link between urea and Hb

Answer 12

Ur rise = AKI or upper GI haemorrhage

Hb broken down by gastric acid into Ur, then absorbed into blood

In an upper GI H’gge you may fine a low Hb, Ur rise.

nb isolated urea rise (without Creatinine rise may be seen in pre-renal causes of renal failure e.g. DEHYDRATION)

Question 13

Causes of pre-renal AKI

Answer 13

Pre-renal = U rise > C rise (U x 10 > C).

• Dehydration (or if severe, shock) e.g. sepsis, blood loss.
• Renal artery stenosis (often triggered by drugs e.g. ACEi or NSAIDs; renal hypoperfusion)

Question 14

Causes of renal AKI

Answer 14

Intrinsic = U rise < C rise, no bladder or hydronephrosis.

INTRINSIC

• ischaemic (prerenal AKI → ATN)
• nephrotoxic antibiotics
  
  • gentamicin, vancomycin + tetracyclines
• tablets
  
  • ACE-i, NSAIDs
• radiological contrast
• injury; rhabdomyolsis
• negatively birefringent crystals (gout)
• syndromes; glomerulonephridites
• inflammation; vasculitis
• cholesterol emboli.

Question 15

Causes of post renal AKI

Answer 15

Post-renal = U rise < C rise, bladder or hydronephrosis.

• In lumen = stone or sloughed papilla.
• In wall = tumour (renal cell, transitional cell), fibrosis.
• External pressure = benign prostatic hyperplasia, prostate cancer, lymphadenopathy, aneurysm.

Question 16

LFT:

1. Markers of hepatocellular injury or cholestasis
2. Synthetic function

Answer 16

1. bilirubin, ALT, AST, ALP.
2. Albumin, vit K dependent clotting factors (2,7,9,10) measure PT/INR

Question 17

Causes of raised bilirubin (3 categories)

Answer 17

• Bilirubin rise only = pre-hepatic e.g.
  
  • haemolysis
  • Gilbert’s syndrome
  • Crigler-Najjar syndrome
• Bilirubin + AST/ALT rise = hepatic e.g.
  
  • fatty liver
  • hepatitis
  • cirrhosis
    
    • Hepatitis + cirrhosis = alcohol, viruses (hepatitis A-E, CMV + EBV), drugs (paracetamol overdose).
  • malignancy; 1⁰ or 2⁰
  • metabolic; Wilson’s, haemochromatosis
  • HF
• Bilirubin + ALP rise = post-hepatic i.e. obstruction…
  
  • In lumen = gallstones, drugs (flucloxacillin, co-amoxiclav, nitrofurantoin, steroids + sulphonylureas).
  • In wall = cholangiocarcinoma, PBC, PSC.
  • External pressure = pancreatic or gastric cancer, lymph nodes.

Question 18

Causes of raised ALP

Answer 18

ALKPHOS

• any fracture
• liver damage (post-hepatic)
• k for kancer
• Paget’s + pregnancy
• hyperparathyroidism
• osteomalacia
• surgery.

Question 19

Thyroid Fynction tests: and Changing levothyroxine!

Answer 19

Check TSH (0.5-5mIU/L), and change by smallest increment offered (unless grossly hypo/hyperthyroid).

• <0.5 = decrease dose
• 0.5-5 = nil action
• >5 = increase dose.

Question 20

Abnormal TFTs: Hypothyroidism

Answer 20

Primary hypothyroidism = ↓T4 from thyroid so ↑TSH from pituitary = Hashimoto’s, drug-induced.

Secondary hypothyroidism = ↓TSH, so ↓T4 = pituitary tumour or damage.

Question 21

Abnormal TFTs: Hyperthyroidism

Answer 21

Primary hyperthyroidism = ↑T4, so ↓TSH = Grave’s, toxic nodular goitre, drug-induced.

Secondary hyperthyroidism = ↑TSH, so ↑T4 = pituitary tumour.

Question 22

Quick review of CXR:

PIPRA + ABCDEFGH

PSA=?pneumonia/pulmonary oedema

Answer 22

PIPRA:

• Projection: PA (N, PA if no markings) or AP (can’t comment on heart) – should see from above clavicles to below diaphragm.
• Inspiration: 7th anterior (down-sloping) rib transects diaphragm.
• Penetration: vertebral bodies behind heart.
• Rotation: distance between spinous processes + clavicles equal.
• Artefact: if present.

ABCDEFGH:

• Airways: trachea central – if not, consider collapse (towards) or pneumothorax (away).
• Bone: rib fractures or lytic lesions.
• Cardiac: cardiothoracic ratio <50% on PA film.
• Diaphragm: air under diaphragm – bowel perforation or recent surgery; under L side is gastric bubble (N).
• Edges: costophrenic + cardiophrenic angles sharp or blunt (effusion).
• Fields: white area = effusion (unilateral + solid), pneumonia (unilateral + fluffy), oedema (bilateral + fluffy), fibrosis (bilateral + honeycomb).
  
  • Oedema, ABCDE = alveolar oedema, kerley B lines, cardiomegaly, diversion of blood to upper lobes, effusions.
  • Sail sign (triangle shape) behind heart = L lower lobe collapse.
• Gynaecomastia + other soft-tissues.
• Hila.

Question 23

Quick review of ABG

Answer 23

• Check inspired oxygen concentration (FiO2):
  
  • Calculate N PaO2 for patient on oxygen: subtract 10 from FiO2, and if PaO2 exceeds this number, then patient not hypoxic.
    
    • E.g. On 60% oxygen with FiO2 of 30kPa actually hypoxic. Accurately done via arterial-alevolar gradient.
• Check for respiratory failure: if PaO2 low or inappropriately N.
  
  • Type 1 = low or N PaCO2 (fast breathing) → heart/lung damage causing SOB.
  • Type 2 = high PaCO2 (slow breathing) → ‘blue-bloaters’ of COPD, NM failure or restrictive chest wall abnormalities.
• Check acid-base status:
  
  • Low pH = acidosis; high pH = alkalosis.
  • PaCO2 abnormal = respiratory. HCO3 abnormal = metabolic. Both = compensation (fully if pH normal, otherwise partial). Both abnormal in opposite directions = mixed.

Question 24

Causes of the 4 acid base abnormalities

Answer 24

Respiratory alkalosis = rapid breathing – disease or anxiety.

Respiratory acidosis = same causes as T2RF. (COPD, blue bloaters, + neuromuscular failure + restrictive chest wall abn)

Metabolic alkalosis = vomiting, diuretics + Conn’s syndrome.

Metabolic acidosis = multiple causes e.g. lactic acidosis, DKA, renal failure, ethanol/methanol/ethylene glycol intoxication → narrow cause by using anion gap.

Question 25

Quick review of ECG interpretation

Answer 25

**Rate**: divide 300 by # of large squares between each QRS complex; N = 60-100bpm. **Rhythm**: p-waves present before QRS = sinus; PR interval not constant or \>1 square = heart block → 1st degree = constant but \>1 square, 2nd degree type 1 = increasing PR then misses a QRS, 2nd type 2 = 2/3 p waves for every QRS, 3rd/complete = no relationship; no p waves + irregular QRS complexes = AF. **Axis**: look at direction of I and II. If I +ve and II +ve = N; If I +ve and II –ve = LAD; If I –ve and II +ve = RAD. **QRS**: width \<3 small squares = N, narrow-complex; \>3 = BBB – WiLLiaM = LBBB, rSR (M shape) in V6, MarRRoW = RBBB, rSR in V1. **QRS height:** Add largest deflection in V1 to V6; \>3.5 large squares = LVH (Sokolov-Lyon); small complexes throughout = pericardial effusion. **ST segment**: elevated = infarction (flat + some leads) or pericarditis (convex + all leads); depressed = ischaemia (flat + some leads) or digoxin (down-sloping, all leads). **T-waves**: height \> 2/3rd QRS height throughout ECG = hyperkalaemia; inversion = N in aVR + I, other leads = old infarction/LVH

Question 26

What criteria would suggest the need for monitoring name 6 common drugs that require monitoring

Answer 26

Drug with _narrow therapeutic index_; small difference in blood concentration for therapeutic + toxic effects require monitoring 1. digoxin 2. theophylline 3. lithium 4. phenytoin 5. ABx: gentamicin 6. ABx: vancomycin

Question 27

What does drug monitoring entale (2 part)

Answer 27

Monitoring 1. assess clinical state * response to drug * evidence of toxicity 2. measure serum drug levels → adjust dose/frequency accordingly

Question 28

For what reasons is the dose/freq of a drug altered (4)

Answer 28

_Inadequate response + low serum drug level_ = increase dose – in general by smallest possible increment, especially if 0-order kinetics (e.g. phenytoin). _Adequate response + N/low serum drug level_ = no change – clinical response more important, as already therapeutic dose! _Adequate response + high serum drug level_ = decrease dose – if toxicity, then can omit for few days (except **gentamicin**). * gent: pre-emptive decrease in frequency by 12hrs (e.g. 36 rather than 24hrs) _Toxicity + any serum drug level_ = (1) stop dose (+ alternative); (2) supportive measures (usually IV fluids); (3) give antidote

Question 29

Common signs of drug toxicity * Digoxin * Lithium * Phenytoin * Gentamicin * Vancomycin

Answer 29

* Digoxin * confusion * nausea * visual halos * arrythmia * Lithium * early: tremor * intermediate: tiredness * Later: arrhythmias * seizures * coma * renal failure * diabetes insipidus * Phenytoin * gum hypertrophy * ataxia * nystagmus * peripheral neuropathy * teratogenicity * Gentamicin * ototoxicity * nephrotoxicity * Vancomycin * ototoxicity * nephrotoxicity

Question 30

Gentamicin normal dosing (&2 exceptions)

Answer 30

Gentamicin monitoring: IV aminoglycoside antibiotic used in severe infections. Doses calculated via weight + renal function. * Most treated with high-dose regimen of 5-7mg/kg once-daily; * Renal failure patient recieve divided daily dosing (1mg/kg) 12-hourly * Endocarditis patients recieve divided daily dosing (1mg/Kg) 8-hourly *Must monitor as high risk of nephrotoxicity + ototoxicity.*

Question 31

Gentamicin: Normal once daily regime monitoring

Answer 31

*Risk of ototoxicity and nephrotoxicity* * Measure gentamicin levels at particular times e.g. 6-14h after last gentamicin infusion started. * Use nomogram (specific to dose). If point on graph falls within 24h area, continue at same dose. If above 24h area, then change dosing: * If in 36h area, change to 36-hourly dosing. * If in 48h area, change to 48-hourly dosing. * If above 48h area, repeat gentamicin level and only re-dose when concentration \<1mg/L. * Change frequency over dose as need sufficient dose to hit peak to hit minimum inhibitory concentration of organism.

Question 32

Gentamicine: divided daily dosing regimes + monitoring

Answer 32

Divided daily dosing: Nomogram exists, but daily peak and trough levels usually used instead. * **Peak** (1hr post dose) if outside of normal range (3-5mg/L (endocarditis) 5-10mg/L (all else)) adjust the **dose** * **Trough** (just before next dose) if outside of normal range (\<1mg/L (endocarditis) \<2mg/L (all else)) adjust the **interval**

Question 33

Management of paracetamol overdose (2)

Answer 33

* Specific = N-acetyl cysteine (NAC) if appropriate. * *Paracetamol metabolised by liver; relies on glutathione which is quickly depleted so toxic NAPQI accumulates. NAC replenishes it.* * Supportive = particularly IV fluids.

Question 34

Warfarin Mechanism of action

Answer 34

Inhibits synthesis of vitamin K-dependent clotting factors (**2, 7, 9 + 10**) – prolongs PT from which INR derived.

Question 35

What is INR?

Answer 35

INR = ratio of patient PT to N population. Normal INR = 1. INR Only used to monitor warfarin – use PT for liver disease/ DIC

Question 36

Target INRs

Answer 36

Target INR for most = **2.5** if recurrent thromboembolism while on warfarin or metal replacement heart valves INR = **3.5.**

Question 37

If major bleed on warfarin i.e. causing hypotension or bleeding in confined space (brain or eye):

Answer 37

1. Stop **warfarin** 2. give 5-10mg **IV vitamin K** 3. give **prothrombin complex** (e.g. Beriplex) : this if factors 2,7,9,10. If not avaliable give fresh frozen plasma

Question 38

How to manage over coagulation (in minor bleeding or no bleeding)

Answer 38

If not bleeding, then look at INR to judge next step: * **INR \<5** = reduce warfarin dose. * **INR 5-8** = omit 1 or 2 doses of warfarin then reduce dose. * **INR \>8** = omit warfarin + give *1-5mg oral vitamin K (phytomenadione)* If ***minor*** bleeding, with **INR \>5**, give ***_IV instead of oral vitamin K._*** * **INR \>5** = stop warfarin + give vit K *_IV instead of oral_* unexpected bleeding at therapeutic levels - always Ix possibility of underlying cause e.g. renal or GI tract pathology