Chapter 5: Pharmacogenomics

Question 1

This enzyme is responsible for the clearance of 5-fluorouracil (5-FU), a first-line prodrug agent for the treatment of colorectal cancer.

Answer 1

Dihydropyrimidine Dehydrogenase (DPD)

Question 2

This enzyme is involved in the hepatic excretion of small molecules into the bile.

It contributes to the clearance of SN-38, the bioactive metabolite of irinotecan, a cytotoxic agent used in the treatment of colorectal cancer.

Answer 2

Uridine 5’-diphospho-(UDP) glucuronosyltransferase (UGT1A1)