Chapter 7 Translocations

Question 1

Ewing Sarcoma

Answer 1

t11;22

Question 2

Chronic myelogenous leukemia (CML)

Answer 2

T(9;22)

Question 3

Acute myeloid leukemia (AML)

Answer 3

Known to be associated with DIC
T(8;21)
T(15;17)

Question 4

Acute promyelocytic leukemia (APML)

Answer 4

T(15;17)

Question 5

Burkitt lymphoma

Answer 5

T(8;14)

Question 6

Mantle cell lymphoma

Answer 6

T(11;14)

Question 7

Follicular lymphoma

Answer 7

T(14;18)

Question 8

Prostatic adenocarcinoma

Answer 8

T(7;21)

T(17;21)

Question 9

Retinoblastoma

Answer 9

Del (13q14)

Question 10

Von Hippel Lindau syndrome

Answer 10

Del (3p)

Question 11

T-cell acute lymphoblastic leukemia

Answer 11

Small deletion of chromosome 1

Question 12

Lung cancers

Answer 12

Deletions involving chromosome 5

EML4-ALK fusion gene

Question 13

MYC

Answer 13

T(8;14)

Burkitt lymphoma

Question 14

NMYC amplification

Answer 14

Chromosome 2p
Double minutes or as a chromosomally integrated homogenous staining region (HSR)
Neuroblastoma

Question 15

Chronic myelogenous leukemia

Answer 15

T(9;22)

ABL tyrosine kinase