Cholesterol

Question 1

Content of lipid rafts

Answer 1

Cholesterol + sphingolipids + GPI

Question 2

Cholesterol derivatives

Answer 2

Vitamin D
Bile salts
Steroid hormones

Question 3

3 steps of cholesterol synthesis

Answer 3

Synthesis of iso
Condensation of 6 x iso —> squalene
Cyclisation of squalene + 19 steps

Question 4

Heart disease cause and what is targeted

Answer 4

Blocked coronary artery
HMG-CoA reductase targeted by drugs such as lovastatin (comp.in.)
Bile acid binders inhibit intestinal reabsorption of bile salts.

Question 5

FH disease

Answer 5

No LDL receptor for cholesterol.
Homozygous die of heartd.
Heterozygotes have heartd. Later