How does chromate interact with insulin
4 steps
Transferrin delivers chromium to receptors
Chromium is released inside the cell
4 chromium atoms form with chromudulin to make holochromodulin
Holochromodulin binds to the Beta sub unit of the insulin receptor to potentiate insulin action
2 characteristics of chromium
Increase insulin action and sensitivity
Chromudulin binds to the beta subunit of the insulin receptor and stimulates
Tyrosine kinase activity
Chromate may inhibit
Activity of phosphotyrosine phosphatase to prolong insulin signaling
Chromium is associated with what hormone
Insulin