class 1c

Question 1

flecanide

Answer 1

action: Block Na+/unchanged repol time
Use: ventricular tachycardia, AFIB w/o sig left ventricular disease or CAD, PSVT (paroxysmal SVT)
notes: effective in His-Purkinje system (QRS widening); may slightly prolong AP duration by reducing Na+ channel inactivation and Ito activity; EXTREMELY PRO-ARRHYTHMIC!

Question 2

propafenone

Answer 2

action: Block Na+/unchanged repol time
Use: ventricular tachycardia, AFIB w/o sig left ventricular disease or CAD, PSVT (paroxysmal SVT)
notes: effective in His-Purkinje system (QRS widening); may slightly prolong AP duration by reducing Na+ channel inactivation and Ito activity; EXTREMELY PRO-ARRHYTHMIC!