1
Q
Which is the most important microsomal enzyme in drug metabolism?
A
Cytochrome P450
2
Q
Classic example of therapeutic failure because liver enzyme induction decreases duration of a drug?
A
OCP when also using rifampicin
3
Q
Which drugs induce liver enzymes
A
Phenobarbitone
Rifampicin
Alcohol - excess
Phenytoin
St John’s Wort
Carbazepine
4
Q
Which drugs inhibit cytochrome P450?
A
Chloramphenicol
Erythromycin
Sulfonamides
Ketoconazole
Isoniazid
Cimetidine
Ciprofloxacin
Ethanol
Allopurinol
Omeprazole
Disulfiram
Sodium valproate
MRCP 1
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