Clindamycin

Question 1

What is the MOA for clindamycin?

Answer 1

1. Protein synthesis inhibitors

2. Binds to 50S subunit at “A site,” blocking peptide bond formation

Question 2

What gram positive bacteria is clindamycin effective against?

Answer 2

1. Streptococci: 15-20% resistance in group B

2. Staph aureus: resistance 30%

Question 3

What gram negative bacteria is clindamycin effective against?

Answer 3

NONE!

Question 4

What anaerobic bacteria is clindamycin effective against?

Answer 4

1. B. fragilis: resistance 30-60%
2. Clostridium
3. Peptostreptococcus
4. Fusobacterium
5. Prevotella: resistance 5-30%

Question 5

What other bacteria is clindamycin effective against?

Answer 5

1. Toxoplasmosis

2. Plasmodium falciparum

Question 6

What are the clinical uses for clindamycin?

Answer 6

1. Alternative to beta lactams for surgical prophylaxis for PCN allergic pts
2. Alternative treatment for skin and soft tissue infections caused by S. aureus
3. Alternative treatment for toxoplasmosis with pyrimethamine
4. Combination therapy in PCN for toxic shock syndrome
5. Combination therapy with quinine for falciparum malaria
6. Use for aspiration pneumonias!

Question 7

What are the SE for clindamycin?

Answer 7

1. Diarrhea
2. Pseudomonas coilits
3. Greatly increases the chance of C. Dificile infection