Clonal selection

Question 1

the process that highly specific
lymphocyte receptors recognize specific antigen

Answer 1

Clonal selection:

Question 2

clonal expansion is when?

Answer 2

Activated lymphocytes
undergo cell proliferation and differentiation to
form clones of antigen-specific effector cells that mediate adaptive immunity.

Question 3

What is tolerance and what does it do?

Answer 3

tolerance ensures that the immune system avoids destroying host tissue
* Many of the random rearrangements used to create B and T cell receptors
could be anti-self

Question 4

Tolerance:
Lymphocytes with self-reactive receptors are normally eliminated during development or are functionally inactivated →
This leads to…

Answer 4

• Lymphocytes with self-reactive receptors are normally eliminated during development or are functionally inactivated → immune system combats
  foreign antigens, not self-antigens (autoantigens, components of normal
  tissue)

Question 5

Why is tolerance so important?

Answer 5

Tolerance helps to keep these anti-self recognition molecules/cells from
circulating in the bloodstream

Question 6

Immunological memory is hallmark of which type of immunity?

Answer 6

adaptive immunity

Question 7

Explain the steps in immunological memory starting from primary response to second exposure

Answer 7

• Primary response is initiated upon first exposure to an antigen (~14
  days)
  Memory lymphocytes are left behind after antigen is cleared
• A second exposure to the same antigen re-stimulates
  memory lymphocytes reactivated faster (2~3 days), more
  significant, better response (allow vaccines to work)
• Memory is NOT present in innate immunity

Question 8

Is memory present in innate immunity?

Answer 8

NO!!!!!