Clopidogrel

Question 1

Clopidogrel Drug Class

Answer 1

Platelet receptor antagonist

Question 2

Clopidogrel Action

Answer 2

• clopidogrel is a specific and potent inhibitor or platelet aggregation and limits propagation of thrombus by selectively inhibiting the binding of ADP to its platelet receptor
• Clopidogrel is absorbed from the stomach and upper small bowel and begins to inhibit platelet function within 30 minutes

Question 3

Clopidogrel Adverse Effects

Answer 3

• Allergic reactions: asthma, angioneurotic oedema, rhinitis, urticaria, laryngeal oedema and shock
• Aggravation of any bleeding tendency
• Gastric irritation (unlikely to be significant with current dose)
• Bleeding may take longer to stop

Question 4

Clopidogrel Contraindications

Answer 4

• Active, suspected or known bleeding tendency
• Allergy or hypersensitivity to clopidogrel
• Any exvlusion via Prehospital Thrombbolysis Checklist
• Pts <18yrs of age
• Pregnancy or breastfeeding

Question 5

Clopidogrel Preparation

Answer 5

75mg tablet

Question 6

Clopidogrel Use

Answer 6

Cardiac reperfusion - prehospital thrombolysis