Clopidogrel

Question 1

What is clopidogrel?

Answer 1

Clopidogrel (75mg tablet) is an antiplatelet medication which inhibits platelet aggregation.

Hepatic metabolism excreted in the urine & faeces.

Question 2

Indications for clopidogrel?

Answer 2

1. For patients with STEMI (as defined by the relevant QAS CPP) and
   - Who have been accepted for pPCI (as an adjunct medication to aspirin and heparin) and the receiving cardiologist is requesting clopidogrel OR
   - Have received tenecteplase (and have been administered aspirin & enoxaparin)

Question 3

Contraindications for clopidogrel?

Answer 3

1. Allergy / ADR
2. Patients contraindicated for pre-hospital fibrinolysis administration
3. Current clopidogrel OR ticagrelor therapy
4. Patients less than 18 years of age
5. Active bleeding
6. Prior intracranial haemorrhage

Question 4

Precautions for clopidogrel?

Answer 4

1. Severe renal impairment

Question 5

Side effects of clopidogrel?

Answer 5

1. Haemorrhage

Question 6

What is the dose for clopidogrel?

Answer 6

> 18 years

1. For patients with STEMI (as defined by the relevant QAS CPP) and:

a) who have been accepted for pPCO (as an adjunct medication to aspirin and heparin) and the receiving cardiologist is requesting clopidogrel:
600 mg PO
Swallowed with a small quantity of water

b) have received tenecteplase (and have been administered aspirin & enoxaparin)
300 mg PO