Clopidogrel

Question 1

what class of drug is Clopidogrel?

Answer 1

Antiplatelet drug

Question 2

Clopidogrel Indications?

Answer 2

• Treatment of ACS in combination of Aspirin
• to Prevent Coronary Artery Stent occlusion
• Secondary prevention of major CVD events in patients at risk

Question 3

Clopidogrel mechanism of action?

Answer 3

• Clopidogrel is metabolised to its active form by carboxylesterase-1,3
• the active form is a platelet inhibitor that binds to P2Y12 ADP receptors on platelets.
• The binding prevents ADP binding to the P2Y12 receptors, activation of the glycoprotein GPllb/llla complex, and platelet aggregation

Question 4

Clopidogrel contradictions ?

Answer 4

• Active GI bleeding
• Active Cranial bleeding
• Severe hepatic impairment
• Pregnancy
• Breastfeeding

Question 5

Clopidogrel caution?