Coagulase Cascade

Question 1

Intrinsic pathway

Answer 1

XII—->XIa
|
XI—–>XIa
| Ca(++)
IX—–>IX+ VIIa & PL + Ca(++)

Question 2

Extrinsic pathway (coagulation cascade)

Answer 2

TF+ VII
|
Ca(++) + VIIa

Question 3

Common pathway (coagulation cascade)

Answer 3

X
|
(+Intrinsic complex) Xa (+extrinsic complex)
|
Xa
|
Xa+Va & PL + Ca(++)
|
Prothrombin–>thrombin—>XII—->XIIa
Fibrinogen+thrombin—>fibrin+XIIa—> crosslinked fibrin

Question 4

Intrinsic Xase complex

Answer 4

IX+ VIIIa
PL+ Ca(++)

Question 5

Extrinsic Xase complex

Answer 5

Tissue factor
Ca(++) + VIIa

Question 6

Prothrombinase complex

Answer 6

Xa + Va
PL + Ca(++)

Question 7

I (coagulation cascade)

Answer 7

Fibrinogen

Question 8

II (coagulation cascade)

Answer 8

Prothrombin

Question 9

III (coagulation cascade)

Answer 9

Tissue factor

Question 10

IV (coagulation cascade)

Answer 10

Calcium

Question 11

V (coagulation cascade)

Answer 11

Proaccelerin

Question 12

VII (coagulation cascade)

Answer 12

Proconvertin, stable factor

Question 13

VIII (coagulation cascade)

Answer 13

Antihemophilic factor

Question 14

VWF (coagulation cascade)

Answer 14

Von Willebrand factor

Question 15

IX (coagulation cascade)

Answer 15

Plasma thromboplastin component

Question 16

X (coagulation cascade)

Answer 16

Stuart factor

Question 17

XI (coagulation cascade)

Answer 17

Plasma thromboplastin antecedent

Question 18

XII (coagulation cascade)

Answer 18

Haegeman factor

Question 19

XIII (coagulation cascade)

Answer 19

Fibrin stabilizing factor

Question 20

HK (coagulation cascade)

Answer 20

Fitzgerald factor, Williams factor, Flaujeac factor

Question 21

PK (coagulation cascade)

Answer 21

Fletcher factor

Question 22

PL (coagulation cascade)

Answer 22

Platelet phospholipid

Question 23

TF (coagulation cascade)

Answer 23

Tissue factor

Question 24

Prothrombin group of coagulation

Answer 24

Factors: 2, 7, 9, 10
Vit K dependent

Question 25

Fibrinogen group of coagulation

Answer 25

Factors: 1, 2, 5, 8, 13 Not found in serum

Question 26

Contact group of coagulation

Answer 26

Factors: 11, 12, PK (prekallekrein), HK (high molecular weight kininogen) Activate intrinsic pathway

Question 27

Cofactors of coagulation

Answer 27

Factors 5, 8 Cofactors of 10, 9

Question 28

Substrates of coagulation

Answer 28

Fibrinogen

Question 29

Enzymes of coagulation

Answer 29

Factors: 7, 9, 10, 11, 12 Cleave arginine/lysine Factor 13- transglutaminase activity catalyzes formation of peptide bonds btwn glutamine & lysine on fibrin making cross links in fibrin meshwork