Coagulation

Question 1

Why can liver disease lead to an inability to coagulate?

Answer 1

• Many Coagulation Proteins are made in the Liver

Question 2

What must happen for a zymogen to get activated?

Answer 2

• Must have protease cleave a portion to convert the -ogen to an active protein

Question 3

What happens has a result of cleaving the following zymogens?

• X
• Fibrinogen

Answer 3

X —> Xa, protein is cleaved and activated to give it PROTEASE activity

Fibrinogen —> Fibrin, protein is cleaved allowing it to form AGGREGATES

Question 4

What does fibrinogen do when it gets bound to Xa?

Answer 4

Accelerates coagulation by 1000x

Question 5

What happens when proteins (factor VII receptor) on non-vascular cells are exposed to the blood?

Answer 5

Proteins on their surface trigger initiation of coagulation response

Question 6

How are downstream clots prevented in the clotting response?

Answer 6

• Anti-coagulation Proteins displayed by endothelial cells bind other Anti-coagulation proteins and destroy Accelerators of coagulation

Question 7

What is the structural Protein of a clot?

Answer 7

Fibrinogen/Fibrin

Question 8

What is the purpose of fibrin crosslinking in the clotting response?

Answer 8

• Makes the Clot strong enough to resist hemodynamic and other forces