Coagulation Studies

Question 1

• What are the vitamin K clotting factors

Answer 1

2, 7, 9, 10

Question 2

• What are the goals of coagulation?

Answer 2

• Prevent life-threatening hemorrhage!
• Serve as the first step in wound healing.
• Make coagulation self-limiting and to prevent excessive coagulation: need “homeostasis

Question 3

• What are the 3 processes of hemostasis?

Answer 3

1)Vasoconstriction
2)Formation of a platelet plug
3) Coagulation
Cascade

Question 4

Define platelet adhesion

Answer 4

Deposition of platelets on the exposed sub-endothelial matrix (tunica intima)

Question 5

Define platelet aggregation

Answer 5

Platelet-to-platelet cohesion to form the platelet plug

Question 6

• What does PT check?

Answer 6

Effect of coumadin (Warafin)

Question 7

• What does PTT check?

Answer 7

Heparin

Question 8

*What is bleeding time used to assess?

Answer 8

The vascular (vasoconstriction) and platelet phase of hemostasis

Question 9

Define bleeding time

Answer 9

Time it takes for a platelet plug to form

Question 10

• What are the causes of abn. prothrombin time?

Answer 10

-poor nutrition, malabsorption of vitamin K, liver disease, warafarin therapy, isolated factor VII deficiency

Question 11

• What is vitamin K clotting factor 2?

Answer 11

Prothrombin

Question 12

What is vitamin K clotting factor 1?

Answer 12

Fibrinogen

Question 13

• Deficiency in Factor 8 indicates which disorder?

Answer 13

Hemophilia A

Question 14

*What are 3 natural occuring anticoagulants?

Answer 14

Protein C, Protein S, and Anti-thrombin

Question 15

• What is Factor V Leiden thombophilia

Answer 15

a genetically inherited disorder of thrombophilia.