Complement System Controls

Question 1

C1 Inhibitor (C1-INH)

Answer 1

Inactivates C1r and C1s,

MASP-1 and MASP-2

Question 2

MCP

Answer 2

Cofactor for Factor-I mediated cleavage of C3b and C4b

Question 3

DAF

Answer 3

Destabilizes C3/C5 convertase of CP and AP

Question 4

CR1

Answer 4

Decay Acc. activity

Cofactor for Factor-I mediated cleavage of C3b and C4b

Question 5

C4 Binding Protein (C4BP)

Answer 5

Binds to C4b

Decay Acc. activity

Question 6

Factor H

Answer 6

Binds to C3b

Delay Acc. activity of AP C3 and C5 convertases

Question 7

Factor I

Answer 7

Degrades C3b and C4b with help of cofactors

Question 8

CD59

Answer 8

Blocks C9 association of C5b-8

Prevents MAC formation

Question 9

S-protein (vitronectin)

Answer 9

Binds to C5b-7 and inhibits C9 polymerization

Question 10

Clusterin

Answer 10

Binds to C5b-7 and inhibits generation of C5b-9