Causes of primary amenorrhoea
4 Causes
Turner’s Syndrome (XO)
Testicular Feminisation
Congenital Adrenal Hyperplasia
Congenital Malformations of the Genital tract
Causes of secondary amenorrhoea
7 Causes
Hypothalamic (Stress and exercise) PCOS Hyperprolactinaemia Premature ovarian failure Thyrotoxicosis/ Hypothyroidism Sheehan's Syndrome Asherman's Syndrom
Initial investigations for secondary amenorrhoea
Pregnancy Gonadotrophins (If low, think hypothalamic. If high, think ovarian) Prolactin Androgen Levels (PCOS) Oestradiol Thyroid function tests
Causes of hirsutism
PCOS cushing's syndrome Congenital Adrenal Hyperplasia Androgen therapy Obesity Adrenal tumour Androgen secreting ovarian tumour Drugs : Phenytoin
Bulky uterus and longstanding menorrhagia. Awaiting TVUS
Management?
a) IUS B)GnRH Agonist c) Aspirin d) tranexamic acid e) COCP
Tranexamic
Even though sounds like fibroids, need to visualise anatomy before putting in the IUS
Stage I and II Endometrial carcinoma.
First line management
TAH + BSO
Stage IIb endometrial carcinoma
Management?
Wertheim’s radical hysterectomy