CONTRACEPTION INTERACTIONS

Question 1

Enzyme inducers

Answer 1

Griseofluvin - effectiveness of POP may be reduced
Ulipristal - effectiveness may be reduced
REMEMBER ‘CRAPPS’ ENZYME INDUCERS! Carbamazepine, Rifampicin, Aprepitant, Phenytoin, Phenobarbital,
St John’s Wort - reduce effectiveness of POPs

Question 2

Ulipristal

Answer 2

Efficacy reduced by drugs that increase gastric pH
- Antacids
- H2 receptor antagonists
- PPIs

Question 3

What should be done if a patient is taking a progesterone-only pill alongside an enzyme-inducing drug e.g., carbamazepine or phenobarbital?

Answer 3

additional barrier method is recommended, during taking and for 28 days after!