Controlled medication- Phosphodiaesterase-4 inhibitors

Question 1

Roflumilast
(daliresp)
Dosage form

Answer 1

Tablets

Question 2

Roflumilast
(daliresp)
Dosing

Answer 2

Adult
-250 mcg daily for 4 weeks followed by 500 mcg by mouth daily
COPD only

Question 3

Adverse Effect

Answer 3

• AE: HA, weight loss, diarrhea, nausea * Monitoring: liver function test, weight * DI: CYP3A4 (major), CYP1A2 (minor) * CI: Child-Pugh class B or C