cortisol

Question 2

Actions of cortisol: increases…

Answer 2

• lipolysis: increase FFA. excess–> inc total cholesterol, decreased HDLs• glucose: promotes gluconeogenesis, inhibits uptake into muscle and fat• BP• protein catabolism–> more aa for gluconeogenesis

Question 3

Actions of cortisol: decreases…

Answer 3

• ADH, to increase water clearance• eosinophils

Question 4

What are the 3 gluconeogenic enzymes that cortisol upregulates?

Answer 4

1. glucose-6-phosphatase2. fructose 1,6-bisphosphatase3. PEPCK: phosphoenol pyruvate carboxykinase

Question 5

non metabolic actions of cortisol….

Answer 5

• positive inotropic action on heart• increase serum calcium• increase GFR, renal blood flow, free water clearance• inhibit fibroblast proliferation and collagen formation• stimulates production of surfactant• inhibits immune function