Cross-modular enzymes

Question 1

Defects in what enzyme cause Alkaptonuria?

Answer 1

homogentisate 1,2-dioxygenase (HGD)

Converts homogentisic acid –> methylacetoacetic acid

Question 2

Defects in what enzyme cause Phenylketonuria (PKU)?

Answer 2

Phenylalanine hydroxylase

Converts phenylalanine –> tyrosine

Question 3

Defects in what enzyme cause Oculocutaneous albinism?

Answer 3

Tyrosinae

Converts hydroxyphenylpyruvic acid –> DOPA