CYP 1A2 Review

Question 1

Fluvoxamine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 1

POTENT INHIBITOR

substrate

Question 2

Clozapine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 2

major substrate

Question 3

Carbamazepine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 3

Inducer

Question 4

St. John’s Wort

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 4

Inducer

Question 5

TCAs

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 5

Substrate

Question 6

Tobacco/smoking

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 6

Inducer

Question 7

Fluoxetine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 7

Inhibitor

Question 8

Caffeine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 8

INHIBITOR

+substrate

Question 9

Olanzapine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 9

Substrate

Question 10

Duloxetine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 10

Substrate

Question 11

Mirtazapine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 11

Substrate

Question 12

Paroxetine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 12

Inhibitor

Question 13

Modafinil

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 13

Inducer

Question 14

Sertraline

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 14

Inhibitor

Question 15

Theophylline

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 15

Substrate

Question 16

OCP

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 16

Strong Inhibitor

Question 17

Estradiol

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 17

Strong Inhibitor

Question 18

Ciprofloxacin

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 18

Inhibitor

Question 19

Risperidone

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 19

Substrate

Question 20

Asenapine

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 20

Substrate

Question 21

Phenytoin

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 21

Inducer

Question 22

Haldol

CYP 1A2 Inducer, Substrate or Inhibitor?

Answer 22

Susbtrate

Question 23

What effect would prescribing fluvoxamine have on Clozapine levels in a patient already on clozapine

Answer 23

would increase clozapine levels–> fluvoxamine is a potent 1A2 inhibitor and clozapine is a 1A2 substrate

Question 24

What effect would prescribing carbamazepine have on duloxetine levels if they were to be co prescribed

Answer 24

decreased duloxetine levels–> carbamazepine is an inducer of 1A2, and duloxetine is a 1A2 substrate

Question 25

Name an antidepressant you should not prescribe with theophylline

Answer 25

fluvoxamine --> potent 1A2 inhibitor --> also avoid sertraline, fluoxetine and paroxetine, but fluvoxamine is the worst

Question 26

St. Johns Wort can work to DECREASE levels of which psychiatric medications?

Answer 26

Clozapine Duloxetine Fluvoxamine Olanzapine Mirtazapine TCAs Risperidone Asenapine Haldol

Question 27

list the CYP 1A2 inhibitors

Answer 27

Fluvoxamine +++ Fluoxetine Paroxetine Sertraline OCP ++ Estradiol ++ Caffeine Cipro, cimetidine, fluoroquinolones

Question 28

List the inducers of CYP 1A2

Answer 28

Carbamazepine St. Johns Wort Phenytoin Modafinil Phenobarbital Tobacco/Smoking Rifampin, ritovanir, omeprazole

Question 29

List the substrates of CYP1A2

Answer 29

Clozapine Fluvoxamine Duloxetine Mirtazapine Olanzapine TCAs Risperidone Asenapine Haldol Agomelatine Ropinirole Theophylline Warfarin Caffeine Naproxen