PRP2 > Cyp450 > Flashcards

Cyp450 Flashcards

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1
Q

Common drugs that are CYP450 inducers?

A

Carbamazepine
Rifampacin
Alcohol
Phenytoin
Griseofluvin
Phenobarbitone
Sulphonyureas

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2
Q

Common CYP450 Inhibitors?

A

Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol & Grapefruit juice
Chloramphenicol
Erythromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole

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3
Q

CYP450 Substrates?

A

Warfarin
Corticosteroids
Oral contraceptives
Aminophylline/theophylline
Statins
Tricyclic Antidepressant

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4
Q

What do CYP inhibitors do to substrates?

A

Increases plasma concentration

Therefore increases toxicity risk

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5
Q

What do CYP inducers do to Substrates?

A

Decreases plasma concentration which can lead to ineffectiveness

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