DAAs

Question 1

glecaprevir/pibrentasvir

Answer 1

Mavyret
Do not use with select statins (atorvastatin, lovastatin, simvastatin), select PI (atazanavir, darunavir, lopinavir,, ritonavir)
>100 mg cyclosporine qd OR ethinyl estradiol > 20 mcg qd

Question 2

sofosbuvir/velpatasavir

Answer 2

Epclusa
Do not use with amiodarone (may cause bradycardia)
do not use with antacids, H2RAs. Separate from antacids by 4 hours. Take H2Ras at the same time or seperated by at least 12 hours and use famotidine < 40 mg BID
Avoid concurrent use of PPIs

Question 3

Sofosbuvir/ledipasvir

Answer 3

Harvoni
Do not use with amiodarone (may cause bradycardia)
do not use with antacids, H2RAs. Separate from antacids by 4 hours. Take H2Ras at the same time or seperated by at least 12 hours and use famotidine < 40 mg BID
Avoid concurrent use of PPIs

Question 4

sofosbuvir/velpatasvir/voxilaprevir

Answer 4

Vosevi
Do not use with amiodarone (may cause bradycardia)
do not use with antacids, H2RAs. Separate from antacids by 4 hours. Take H2Ras at the same time or seperated by at least 12 hours and use famotidine < 40 mg BID
Avoid concurrent use of PPIs

Question 5

Sofosbuvir

Answer 5

Sovaldi
Do not use with amiodarone (may cause bradycardia)

Question 6

Elbasvir/grazoprevir

Answer 6

Zepatier
Do not use with cyclosporine, efavirenz, atazanavir, darunavir, lopinavir, tipranavir)