Target Tissue Specificity is determined by
the type and number of receptors for the hormone
hormone receptor sensitivity
the ability to realize the cognate and ignore others
spillover and example
cross-reactivity for a receptor (LH and hCG)
peptide hormones
secretion regulated circulate free cannot cross membranes plasma membrane receptors degraded by the kidney
steroid hormones
biosynthesis is regulated circulate bound to proteins crosses membranes intracellular receptors degraded by the liver