1
Q
donezipil, galantamine, rivastigmine
A
cholinesterase inhibitors, inc ACh
2
Q
cholinesterase inhibitor side effects
A
abdo pain, nausea, diarrhoea
3
Q
memantine
A
partial NMDA antagonist, reduce excitotoxicity and cut out background noise
4
Q
PBT-2 against clioquinol
A
stop aggregation
5
Q
statins
A
ApoE = lipid transport molecule and genetic risk factor - cholesterol metabolism linked to APP
lipid raft partitioning/relieve oxidative stress
6
Q
Bapineuzumab
A
antibody against Abeta - poor outcome in trials but too late?
7
Q
Rember/Taurex (failed trial)
A
stop aggregation of tau
8
Q
paclitaxel
A
Tau can no longer stabilise microtubule - help
9
Q
lithium
A
inhibit GSK3beta (stop hyperphosphorylation)
