DEPRESSION: SNRI

Question 1

MOA

Answer 1

• They inhibit the reuptake of Serotonin and Noradrenaline

Question 2

Examples

Answer 2

Duloxetine
Venlafaxine

Question 3

What are the other indications for duloxetine apart from depression?

Answer 3

• GAD
• Diabetic neuropathy
• Moderate-to-severe stress urinary incontinence (only licensed in females)

Question 4

What are the other indications for venlafaxine other than depression?

Answer 4

• GAD
• Social anxiety
• Panic disorder
• Menopausal symptoms, particularly hot flushes, in women with breast cancer

Question 5

In which condition should SRNIs be avoided in?

Answer 5

• Uncontrolled hypertension

Question 5

What are the common side effects of SRNIs?

Answer 5

• Gl upset
• Headache
• Venlafaxine can prolong QT interval and increase risk of arrhythmia
• Venlafaxine can cause weak antimuscarinic side-effects
• Hypertension