Precursor to melanoma
Atypical nevus
- DEPTH of invasion –> mets
Most common skin cancer, pallisading cells, pearly pink papule with telangiectasias, upper lip, little risk for mets
BCC
Red, scaling/crusty, indurated/ulcerated lesion, on lower lip, arms, back, hands, little risk for mets, sheets and islands of cells with keratin pearls
SCC
- old age, fair skin, p53
Precursor to SCC
Actinic keratosis & Bowen disease (SCC-IS)
“Stuck on,” papillomatous epithelial proliferation of basaloid cells w/ horn cysts
Seborrheic keratosis
Pruritic papules and plaques with fine white line that is lace-like over violet skin on the flexor surface of the wrists
Lichen Planus
Rough, scaly papule w/ hyperkeratosis, parakeratosis, atypical keratinocytes
Actinic keratosis
Vesicular lesions on extensor surfaces
Dermatitis herpetiformis = Celiac
Pruritic target lesions on palms and soles
Erythema multiforme - HSV > mycoplasma - drug reactions \+ fever and mucosal = SJS \+ sloughing = TEN
Blisters on dorsal hands, hypertrichosis, hyperpgimentation, elevated serum and urine porphyrin, no abdominal pain
Porphyria cutanea tarda
Sawtooth histology, HCV
Lichen planus
Thrombosis of superficial veins that appear, resolve and reappear elsewhere on the body
Dry scales, with flaking, pruritus on scalp, axilla, external ear
seborrheic dermatitis (dandruff) - Tx = selenium sulfide or hydrocortizone
Flushing of face with spicy foods, papular lesions, conjunctivitis, rhinophyma (large red nose)
Acne rosacea