1
Q
drugs for psoriasis
A
- acitretin
- tazarotene
- calcipotriene, calcitriol
- cyclosporine
- PUVA therapy
- methotrexate
- biologic response modifiers
2
Q
Acitretin
A
- tx severe psoriasis
- teratogenic
3
Q
Tazarotene
A
- psoriasis, acne, photoaging
- active metabolite binds to retinoic acid R’s
4
Q
Calcipotriene, calcitriol
A
- synthetic vit D3- regulates skin cell prod and prolif
- tx plaque-type psorasis
5
Q
Cyclosporine
A
- inhibits calcineurin- inhibits transcription of IL-1 and 2 R’s- blocks T-cell act
- psoriasis, RA, crohn’s dz, liver/heart/kidney/BM transplants
6
Q
Methotrexate
A
- inhibits DHFR, and suppresses immunocompetent skills in skin
- psoriasis, mult cancers, RA
7
Q
Biologic response modifiers used to treat psoriasis
A
- Alefacept
- TNF inhibitors
- Ustekinumab
8
Q
Alefacept
A
- immunosuppressive dimeric fusion protein- consists of CD2-binding portion of human leukocyte fxn ag-3 linked to FC portion of human IgG1
- interferes w lymphocyte act
9
Q
TNF inhibitors
A
- Etanercept- binds to 2 molecules of TNF
- Infliximab- binds to TNF
- Adalimumab- binds to TNF
- evaluate for TB prior!!!
10
Q
Ustekinumab
A
- IgG1k monoclonal ab- binds to IL-12 and 23- inhibits TH1 and 17 cell-mediated responses
- serious allergic rxns- angioedema, anaphylaxis
11
Q
Anti-infl agents
A
-topical corticosteroids
12
Q
Topical corticosteroids
A
- immunosuppressive and anti-infl
- systemic tx is reserved for severe dermatological illnesses
- hydrocortisone (lowest efficacy), prednisolone, dexamethasone, betamethasone, mometasone, triamcinolone, clobetasol propionate (highest efficacy)
13
Q
Keratolytic and destructive agents
A
- peeling agent- causes softening and dissolution or peeling of stratum corneum and epidermis
- salicylic acid
- fluorouracil
14
Q
Salicylic acid
A
- acne, seborrheic dermatitis, psoriasis, hyperkeratosis
- toxicity can occur
15
Q
fluorouracil
A
-inhibits thymidylate synthetase and blocks syn of DNA and RNA
16
Q
Antipruritic agents
A
-antihistamines
17
Q
Antihistamines
A
- H1-R antagonists
- first generation- diphenhydramine, promethazine- some anticholinergic activity (sedating)
- second gen- no anticholinergic SEs, nonsedating- cetirizine,loratadine, desloratadine, fexofenadine hydrocloride
18
Q
Trichogenic and Antitrichogenic agents
A
- Minoxidil
- Finasteride
- Bimatoprost
- Eflornithine
19
Q
Minoxidil
A
(Rogaine)
-used for androgenic alopecia and hair transplantation
20
Q
Finasteride
A
(propecia)
- tx androgenic alopecia and BPH
- inhibitor of type 2 steroid 5alpha-reductase- blocks T to DHT in prostate gland, seminal vesicles, epididymis, liver, and hair follicles
- SEs- dec libido, ED
21
Q
Agents for Melanoma
A
- BRAF inhibitors- vemurafenib, dabrafenib, trametinib
- Ipilimumab
- Pegylated interferon
22
Q
BRAF inhibitors
A
- tx metastatic melanoma w BRAF mutations
- Vemurafenib, dabrafenib- kinase inhibitors of BRAF V600E mutation- inc risk of new primary cutaneous malignancies
- Trametinib- kinase inhibitor of BRAF B600E and K- inc risk of cardiomyopathy
- all assoc w serious hypersensitivity rxns
23
Q
Ipilimumab
A
- CTLA-4 blocker ab
- tx unresectable or metastatic melanoma
- can cause severe immune-mediated adverse reactions due to T-cell act and prolif
24
Q
Pegylated interferon
A
-adjuvant tx of stage III node-positive melanoma
25
Other antineoplastic agents
- alitretinoin
- bexarotene
- vismodegib
- vorinostat and romidepsin
26
alitretinoin
-tx cutaneous lesions in pts w AIDS-related Kaposi sarcoma
27
Bexarotene
- binds and activates retinoid X R subtypes
- tx cutaneous T cell lymphoma
- teratogenic
- can inc triglycerides and chol
28
Vismodegib
- hedgehog pathway inhibitor
| - tx metastatic BCC or locally advanced BCC
29
Vorinostat and romidepsin
- histone deacetylase inhibitor
| - tx cutaneous T cell lymphoma
30
Antiseborrhea agents
-tx dandruff (seborrheic dermatitis)
M2F
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