Deucravactinib

Question 1

Half life

Answer 1

10 hours

Question 2

Contraindications

Answer 2

Hypersensitivity
Clinically important infection
Concurrent immunosuppressive meds
Sever hepatic impariment

Precautions
- live vaccine
- pregnancy
- BF
- known malignancy
- liver disease

Question 3

Side effects of deucravacitinib

Answer 3

Nasopharyngitis
Urti
Acne
Headache
Folliculitis
Apthous ulcers
Hepatotoxiciry
Increase TGs
Rhabdomyositia
Malignancy

Question 4

HSV rates in deucravacitinib

Answer 4

Less than 1 %

Question 5

Psoriasis response to deucravacitinib

Answer 5

67 - 76 achieve pasi 75 at 12 weeks

Question 6

Dose of deucravacitinib

Answer 6

6mg OD

Question 7

PBS indication for deucravacitinib

Answer 7

Question 8

T/f regarding decravocitinib
- allosteritc inhibitor of TYK2
- orthosteric inhibitor of TYk2
- is associated with VTE
- has a half life of 3 hours

Answer 8

T
F
F
F - 6 hours