Developmental programming and transgenerational effects

Question 1

What is Barker’s hypothesis?

Answer 1

Programming during development

Question 2

What is the equivalent in humans for pregnancy in brain development

Answer 2

first two trimesters

Question 3

What represents the third trimester in mice development?

Answer 3

First 2 postnatal weeks

Question 4

Whht is the mechanisms that makes more GR in hippocampus of high licking pups

Answer 4

More serotonin-> activation of NGFI-A-> binds to 1-7 exon splice varient

Question 5

What is the epigenetic effect found with low vs high lG mothers

Answer 5

Hypermethylation of genes in low LG

Question 6

What is the alternative to methylation that was present?

Answer 6

5-Hydroxymethylcytosine

Question 7

What is the effect on the negative feedback loop of stress?

Answer 7

Decreased negative feedback to the HPA axis

Question 8

Give examples of early-life stress models

Answer 8

Baram-limited bedding model; Mansuy-transgenearational transmission of stress

Question 9

What is the low high LG model called?

Answer 9

Meaney

Question 10

What is the low high LG model called?

Answer 10

Meaney